Endothelial-to-mesenchymal transition (EndMT) in atherosclerosis. This means a patient with the condition may go on to develop atherosclerosis. Endothelial dysfunction, or the loss of proper endothelial function, is a hallmark for vascular diseases, and is often regarded as a key early event in the development of atherosclerosis. Understanding the causes of endothelial dysfunction can help a person realize their own risk of the disease. Endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of atherosclerosis. Endothelial cell (EC) dysfunctions, including turnover enrichment, gap junction disruption, inflammation, and oxidation, play vital roles in the initiation of vascular disorders and atherosclerosis. Endothelial dysfunction Atherosclerosis Hypertension White coat hypertension Coagulation Fibrinolysis Inflammatory mediators Endothelium‐derived relaxing factors … Circular RNA circHIPK3 as a novel circRNA regulator of autophagy and endothelial cell dysfunction in atherosclerosis. Dyslipidaemia is associated with vascular endothelial dysfunction and has been suggested as a contributing factor in the pathogenesis of atherosclerosis. It is also a reversible disorder. Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science Paul C Evans, Paul C Evans Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield and Insigneo Institute for In Silico Medicine , Sheffield, UK. Reduced nitric oxide (NO) bioavailability is a hallmark of chronic kidney disease (CKD), with this disturbance being almost universal in patients who reach the most advanced phase of CKD, end-stage kidney disease (ESKD). Authors; Authors and affiliations; David G. Harrison; Conference paper. Our understating of the role of endothelial dysfunction in the development of cardiovascular disease such as myocardial infarction (MI) or stroke is increasing. Recent studies on endothelial dysfunction in relation to vascular diseases including atherosclerosis have highlighted the key contribution of the microenvironment of endothelial cells (ECs). –) production and oxidative stress play important roles in endothelial dysfunction and atherosclerosis. A total of 131 consecutive patients with non-obstructive coronary artery atherosclerosis were enrolled. Atherosclerosis is a manifestation of the imbalance between vascular injury and protection mechanisms, especially in endothelial dysfunction. 7 Touyz RM. 24 - N. 24 Pages: 12849-12858 DOI: 10.26355/eurrev_202012_24187 Curr Hypertens Rep 2000 ; 2 : 98-105. Endothelial dysfunction may play a key role in non-obstructive coronary artery atherosclerosis. Atherosclerosis occurs as a result of organized processes that include vascular endothelial dysfunction, lipid accumulation, abnormal inflammatory reaction, excessive reactive oxygen species production, and vascular cell proliferation and migration. To date, the vascular endothelium must be considered as a specific organ with its own functions that contribute to the homeostasis of the cardiovascular system. Research Atherosclerosis. against endothelial dysfunction and TMAO-dependent atherosclerosis. 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